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HDAC Inhibition Sensitizes Pancreatic Tumors to DNA Damage by Global Redistribution of the Transcriptional Machinery

2026-05-19

Abstract excerpt

<h4>ABSTRACT</h4> The DNA damage response (DDR) is critical for pancreatic ductal adenocarcinoma (PDAC) development and therapeutic responses, including to genotoxic agents. While epigenetic modulators have been shown to contribute to the DDR, how chromatin regulation dictates responses to DNA damage in PDAC remains incompletely understood. Here, we identify Class I histone deacetylases (HDACs) as critical regula...

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Literature Corpus work
be4301e7-48e9-56be-a6a7-687b8a00fbcf
DOI
10.64898/2026.05.18.726071
Open publication

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HDAC Inhibition Sensitizes Pancreatic Tumors to DNA Damage by Global Redistribution of the Transcriptional MachineryDOI 10.64898/2026.05.18.726071
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