Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Epigenetic Approach to Pancreatic Cancer Treatment: The Prospective Role of Histone Deacetylase Inhibitors

1 Apr 2012

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is quite resistant to conventional treatments, and gemcitabine, the standard chemotherapeutic agent, offers only a small benefit. Development and progression of PDAC are complex processes involving dysregulation of multiple signal transduction pathways arising from not only genetic but also epigenetic alterations. This makes the epigenetic approach to the treatment of PDAC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22309455
DOI: 10.2174/156800912800190884

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Epigenetic Approach to Pancreatic Cancer Treatment: The Prospective Role of Histone Deacetylase InhibitorsPMID 22309455Read ↗

Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects.Semantic proximity Read ↗

Epigenetic targeting in pancreatic cancerSemantic proximity Read ↗

Synergistic Antitumoral Effect of Epigenetic Inhibitors and Gemcitabine in Pancreatic Cancer CellsSemantic proximity Read ↗

Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and TreatmentSemantic proximity Read ↗

Epigenetic Landscape in Pancreatic Ductal Adenocarcinoma: On the Way to Overcoming Drug Resistance?Semantic proximity Read ↗

Advances in pancreatic cancer epigenetics: From the mechanism to the clinicSemantic proximity Read ↗

The Promise of Epigenomic Therapeutics in Pancreatic CancerSemantic proximity Read ↗

New therapeutic targets in pancreatic cancer.Semantic proximity Read ↗

Leveraging epigenetic alterations in pancreatic ductal adenocarcinoma for clinical applicationsSemantic proximity Read ↗

Epigenetic Therapeutic Strategies to Target Molecular and Cellular Heterogeneity in Pancreatic CancerSemantic proximity Read ↗

Class I and Class II Histone Deacetylases Are Potential Therapeutic Targets for Treating Pancreatic CancerSemantic proximity Read ↗

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.