Article

Requirement of DNMT1 to orchestrate epigenomic reprogramming during NPM-ALK driven T cell lymphomagenesis

2020-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Malignant transformation depends on genetic and epigenetic events that result in a burst of deregulated gene expression and chromatin changes. To dissect the sequence of events in this process, we used a T cell-specific lymphoma model based on the human oncogenic NPM-ALK translocation. We find that transformation of T cells shifts thymic cell populations to an undifferentiated immunophenotype, w...

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Literature Corpus work: be130e10-b4bb-5a40-9999-4024340d4c87
DOI: 10.1101/2020.04.09.033373

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