Article

Hyper-proliferation of Adipose Progenitors During Developmental Adipogenesis Programs Higher Adipocyte Number and Early-onset Obesity in Offspring Born to Obese Dams

2025-09-17

Abstract excerpt

<h4>ABSTRACT</h4> Being born to a mother who was obese during pregnancy is one of the strongest predictors of early onset obesity and metabolic syndrome. To identify the developmental mechanism linking maternal obesity to cardiometabolic disease in the offspring, a high fat/high fructose diet or low-fat control diet were introduced 4 weeks prior to mating in C57BL6 females and continued throughout pregnancy and l...

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Literature Corpus work: be12143e-0a54-585a-9362-bfba748ae98c
DOI: 10.1101/2025.09.13.676029

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