Article

Maternal Obesity Reprograms Differentiation Trajectories of Fetal Hematopoietic Stem and Progenitor Cells Through Altered Inflammatory Signaling

2026-02-03

Abstract excerpt

<h4>Background</h4> Maternal obesity is a global health challenge with profound consequences for offspring health. While its impact on metabolic programming has been widely studied, far less is known about how maternal obesity shapes the fetal immune system. The fetal bone marrow (FBM) is the central site of hematopoietic stem and progenitor cell (HSPC) development, and disruptions in this niche can have lifelong...

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Literature Corpus work: 316f2988-8f60-54ec-9154-4f0fdd11697e
DOI: 10.64898/2026.01.29.702548

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