Article

Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 <i>in vivo</i>

2021-03-09

Abstract excerpt

Machado-Joseph disease (MJD, also known as spinocerebellar ataxia-3) is a fatal neurodegenerative disease that impairs control and coordination of movement. Here we tested whether treatment with the histone deacetylase inhibitor sodium valproate (SV) prevented a movement phenotype that develops in larvae of a transgenic zebrafish model of the disease. We found that treatment with SV improved the swimming of the MJ...

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Literature Corpus work: bdee1afa-3b33-512b-80a6-a11e8d8bac46
DOI: 10.1101/2021.03.08.434343

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