Article

Spermidine for the treatment of Machado-Joseph disease: induction of autophagy but also apoptosis?

2023-10-31

Abstract excerpt

<title>Abstract</title> <p>Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis. It is caused by the autosomal dominant inheritance of a long CAG trinucleotide repeat sequence within the ATXN3 gene, encoding for an expanded polyglutamine (polyQ) repeat sequence within the...

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Literature Corpus work: dd4b3482-eeb3-5951-a0d4-838ae3a106c6
DOI: 10.21203/rs.3.rs-3478869/v1

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