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Autophagy in Spinocerebellar Ataxia Type 3: From Pathogenesis to Therapeutics

17 Apr 2023

Abstract excerpt

Machado–Joseph disease (MJD) or spinocerebellar ataxia 3 (SCA3) is a rare, inherited, monogenic, neurodegenerative disease, and the most common SCA worldwide. MJD/SCA3 causative mutation is an abnormal expansion of the triplet CAG at exon 10 within the ATXN3 gene. The gene encodes for ataxin-3, which is a deubiquitinating protein that is also involved in transcriptional regulation. In normal conditions, the...

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PMID: 37108570
DOI: 10.3390/ijms24087405

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