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Article

Pharmacological Therapies for Machado-Joseph Disease.

Advances in experimental medicine and biology - 1 Jan 2018

Duarte-Silva Sara, Maciel Patrícia

Abstract excerpt

Machado-Joseph disease (MJD), also known as Spinocerebellar Ataxia type 3 (SCA3), is the most common autosomal dominant ataxia worldwide. MJD integrates a large group of disorders known as polyglutamine diseases (polyQ). To date, no effective treatment exists for MJD and other polyQ diseases. Nevertheless, researchers are making efforts to find treatment possibilities that modify the disease course or alleviate...

Topics

Humans
Machado-Joseph Disease
Mitochondrial Diseases
Mutation
Neuroimaging
Oxidative Stress
Peptides
Proteolysis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29427114
DOI: 10.1007/978-3-319-71779-1_19

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