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Article

Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4.

PloS one - 1 Jan 2013

Yi Jiping, Zhang Li, Tang Beisha, Han Weiwei, Zhou Yafang, Chen Zhao, Jia Dandan, Jiang Hong

Abstract excerpt

Spinocerebellar ataxia type 3 (SCA3) also known as Machado-Joseph Disease (MJD), is one of nine polyglutamine (polyQ) diseases caused by a CAG-trinucelotide repeat expansion within the coding sequence of the ATXN3 gene. There are no disease-modifying treatments for polyQ diseases. Recent studies suggest that an imbalance in histone acetylation may be a key process leading to transcriptional dysregulation in polyQ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23382971
DOI: 10.1371/journal.pone.0054792
PMCID: PMC3557284

Genes

ATXN3

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