Article

Graph neural network–based prediction of direct reprogramming factors using gene regulatory networks with microRNA-mediated regulation

2026-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Direct reprogramming (DR) converts somatic cells directly into target cell types while bypassing an intermediate pluripotent state, such as induced pluripotent stem cells. In practice, DR is achieved by transfecting multiple transcription factors (TFs); prior research has shown that combining microRNAs (miRNAs) with TFs further improves reprogramming efficiency. However, experimentally identifyi...

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Literature Corpus work: 27151088-2c25-5adf-9c88-ad80872b319e
DOI: 10.64898/2026.01.28.702229

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