Article
Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production.
International journal of obesity (2005) - 1 Sept 2007
Zeyda M, Farmer D, Todoric J, Aszmann O, Speiser M, Györi G, Zlabinger G J, Stulnig T M
Abstract excerpt
OBJECTIVE: Obesity is associated with a chronic low-grade inflammation and an increased abundance of macrophages in adipose tissue. Adipose tissue macrophages (ATMs) are assumed to interfere with adipocyte function leading to insulin resistance, thereby contributing to the pathogenesis of type 2 diabetes mellitus. Macrophages exist in separate types of differentiation, but the nature of ATMs is largely unknown....
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