Article

Targeting of mitochondrial and cytosolic substrates of tRNA isopentenyltransferases: selection of differential tRNA-i6A37 identity subsets

2019-07-25

Abstract excerpt

<h4>ABSTRACT</h4> tRNA isopentenyltransferases (IPTases), which add an isopentenyl group to N 6 of adenosine-37 (i6A37) of certain tRNAs, are among a minority of modification enzymes that act on both cytosolic and mitochondrial substrates. The Caenorhabditis elegans mitochondrial IPTase impacts life expectancy, and pathogenic mutations to human IPTase (TRIT1) that decrease i6A37 levels cause mitochondrial insuf...

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Literature Corpus work: bda168fc-867c-5db7-83b4-29cb9fb46f6e
DOI: 10.1101/714972

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