Back to search

Article

A Novel Heme-Degrading Enzyme that Regulates Heme and Iron Homeostasis and Promotes Virulence in <i>Enterococcus faecalis</i>

2025-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Enterococcus faecalis , a gut commensal, is a leading cause of opportunistic infections. Its virulence is linked to its ability to thrive in hostile environments, which includes host-imposed metal starvation. We recently showed that E. faecalis evades iron starvation using five dedicated transporters that collectively scavenge iron from host tissues and other iron-deprived conditions. Interesti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e2b9acb2-b433-5660-8e00-78d50548dda3
DOI
10.1101/2025.01.20.633879
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Novel Heme-Degrading Enzyme that Regulates Heme and Iron Homeostasis and Promotes Virulence in <i>Enterococcus faecalis</i>DOI 10.1101/2025.01.20.633879
A novel <i>Enterococcus faecalis</i> heme transport regulator (FhtR) is a heme sensor in the gastrointestinal tractSemantic proximity
A Novel Enterococcus faecalis Heme Transport Regulator (FhtR) Senses Host Heme To Control Its Intracellular HomeostasisSemantic proximity
Major role of iron uptake systems in the intrinsic extra-intestinal virulence of the genus <i>Escherichia</i> revealed by a genome-wide association studySemantic proximity
Dual quorum-sensing control of purine biosynthesis drives pathogenic fitness of <i>Enterococcus faecalis</i>Semantic proximity
Reduced glutathione levels in <i>Enterococcus faecalis</i> trigger metabolic and transcriptional compensatory adjustments during iron exposureSemantic proximity
Major role of iron uptake systems in the intrinsic extra-intestinal virulence of the genus Escherichia revealed by a genome-wide association study.Semantic proximity
Functional and genetic adaptations contributing to <i>Enterococcus faecalis</i> persistence in the female urinary tractSemantic proximity
<i>Ruminococcus gnavus</i>: friend or foe for human healthSemantic proximity
Uropathogenic <i>Escherichia coli</i> wield enterobactin-derived catabolites as siderophoresSemantic proximity
Conditionally essential genes for survival during starvation in <i>Enterococcus faecium</i> E745Semantic proximity
In vivo growth of <i>Staphylococcus lugdunensis</i> is facilitated by the concerted function of heme and non-heme iron acquisition mechanismsSemantic proximity
Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus VirulenceSemantic proximity
Select a neighboring publication to make it the new centre.