Article

Molecular mechanism of NAD <sup>+</sup> binding to the Nudix homology domains of DBC1

2023-10-28

Abstract excerpt

DBC1 (deleted in breast cancer 1) is a human nuclear protein that modulates the activities of various proteins. NAD + (oxidized form of nicotinamide adenine dinucleotide) is thought to potentially bind to the Nudix homology domains (NHDs) of DBC1, thereby regulating DBC1-PARP1 [poly (adenosine diphosphate–ribose) polymerase] interactions, the modulation of which may restore DNA repair to protect against cancer, r...

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Literature Corpus work: bd8b8206-9a56-5797-b8a9-df8c57428c6f
DOI: 10.1101/2023.10.27.564493

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