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Article

Intersection of rare pathogenic variants from TCGA in the All of Us Research Program v6.

HGG advances - 10 Apr 2025

Bates Blaine A, Bates Kylee E, Boris Spencer A, Wessman Colin, Stone David, Bryan Justin, Davis Mary F, Bailey Matthew H

Abstract excerpt

Using rare cancer predisposition alleles derived from The Cancer Genome Atlas (TCGA) and high cancer prevalence (14% of participants) in All of Us (version 6), we assessed the impact of these rare alleles on cancer occurrence in six broad groups of genetic similarity provided by All of Us: African/African American (AFR), Admixed American/Latino (AMR), East Asian (EAS), European (EUR), Middle Eastern (MID), or...

Topics

Humans
Neoplasms
Genetic Predisposition to Disease
United States
Databases, Genetic
Genome-Wide Association Study
Mutation
Genetic Variation
Alleles

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39799398
DOI: 10.1016/j.xhgg.2025.100405
PMCID: PMC11830373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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