Article

Mechanisms of A-type lamin targeting to nuclear ruptures are disrupted in <i>LMNA</i> - and <i>BANF1</i> -associated progerias

2022-01-15

Abstract excerpt

Mutations in the genes LMNA and BANF1 can lead to accelerated aging syndromes called progeria. The protein products of these genes, A-type lamins and BAF, respectively, are nuclear envelope (NE) proteins that interact and participate in various cellular processes, including nuclear envelope rupture and repair. BAF localizes to sites of nuclear rupture and recruits NE-repair machinery, including the LEM-domain pr...

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Literature Corpus work: 84dc6f46-8e50-5aee-b6b8-13e8a36140f9
DOI: 10.1101/2022.01.14.476371

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