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Gut bacterial metabolite imidazole propionate potentiates Alzheimer’s disease pathology

2025-06-08

Abstract excerpt

<h4>ABSTRACT</h4> The gut microbiome modulates metabolic and neurovascular processes implicated in Alzheimer’s disease and related dementias (ADRD), but the underlying mechanisms remain unclear. Here, we identify the bacterial metabolite imidazole propionate (ImP) as a modifier of ADRD pathology. In a cohort of 1,196 cognitively unimpaired adults, higher plasma ImP levels were associated with lower preclinical co...

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Literature Corpus work
bd741f29-a124-5835-b681-c758370c0dda
DOI
10.1101/2025.06.08.657719
Open publication

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Gut bacterial metabolite imidazole propionate potentiates Alzheimer’s disease pathologyDOI 10.1101/2025.06.08.657719
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