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Article

Gut microbial metabolite imidazole propionate impairs endothelial cell function and promotes the development of atherosclerosis

2024-06-10

Abstract excerpt

<h4>Background</h4> The microbially generated amino acid-derived metabolite imidazole propionate (ImP) contributes to the pathogenesis of type 2 diabetes. However, the effect of ImP on endothelial cell physiology and its role in atherosclerotic coronary artery disease (CAD) is unknown. Using both human and animal model studies, we investigated the potential contributory role of ImP in the development of atheroscl...

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Literature Corpus work
304aa9e4-a418-54b6-88a0-a30709354cbf
DOI
10.1101/2024.06.05.597678
Open publication

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Gut microbial metabolite imidazole propionate impairs endothelial cell function and promotes the development of atherosclerosisDOI 10.1101/2024.06.05.597678
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