Mitophagy in Diabetic Cardiomyopathy: Roles and Mechanisms

Abstract excerpt

Cardiovascular disease is the leading complication of diabetes mellitus (DM), and diabetic cardiomyopathy (DCM) is a major cause of mortality in diabetic patients. Multiple pathophysiologic mechanisms, including myocardial insulin resistance, oxidative stress and inflammation, are involved in the development of DCM. Recent studies have shown that mitochondrial dysfunction makes a substantial contribution to the...

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• Autophagy in Disease and Therapy
• Cardiovascular Function and Risk Factors
• Mitochondrial Function and Pathology