Article

MORFEE: a new tool for detecting and annotating single nucleotide variants creating premature ATG codons from VCF files

2020-03-30

Abstract excerpt

<h4>Summary</h4> Variants in 5’UTR regions that create upstream translation initiation AUG codons are a class of neglected non coding variations. When they associate with a premature stop codon and create upstream open reading frames (uORFs) whose translation competes with that of natural proteins, they can have strong impact on human diseases. We here describe MORFEE, a new bioinformatics tool that detects, anno...

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Literature Corpus work: 876401a5-64d6-56bb-9c20-2751bfade129
DOI: 10.1101/2020.03.29.012054

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