Article

DUSP11 is an intracellular innate immune checkpoint in lung adenocarcinoma

2025-01-27

Abstract excerpt

The discovery of immune checkpoints and the rapid growth of immuno-oncology (IO) have sparked tremendous efforts to utilize the immune system to treat a wide range of cancer types/subtypes. While the major focus of IO over the past decades has been to manipulate the adaptive immune system, recent attention has been given to manipulating the innate immune system to treat cancer and/or to enhance adaptive responses....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd328c30-5a84-5d5d-b0c8-d019e0214e4f
DOI: 10.1101/2025.01.24.634797

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DUSP11 is an intracellular innate immune checkpoint in lung adenocarcinomaDOI 10.1101/2025.01.24.634797Read

SLC7A11 inhibits ferroptosis and downregulates PD-L1 levels in lung adenocarcinomaSemantic proximity Read

XIST/miR-34a-5p/PDL1 axis regulated the development of lung cancer cells and the immune function of CD8<sup>+</sup> T cellsSemantic proximity Read

Dual-specific phosphatase 5 (DUSP5), upregulated in lung adenocarcinoma, as a potential therapeutic target for lung cancer.Semantic proximity Read

NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activitySemantic proximity Read

NLRP4 negatively regulates type I interferon response and influences the outcome in anti-programmed cell death protein (PD)-1/PD-ligand 1 therapy.Semantic proximity Read

The Aryl Hydrocarbon Receptor Controls IFNγ-Induced Immune Checkpoints PD-L1 and IDO via the JAK/STAT Pathway in Lung AdenocarcinomaSemantic proximity Read

PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillanceSemantic proximity Read

Tumor cell intrinsic RIG-I activation co-opts the host microenvironment to drive immune mediated tumor rejectionSemantic proximity Read

Heterogeneous Expression of PD-L1, B7x, B7-H3, and HHLA2 in Pulmonary Sarcomatoid Carcinoma and the Related Regulatory Signaling PathwaysSemantic proximity Read

DNA-PK inhibition sustains the antitumor innate immune response in small cell lung cancerSemantic proximity Read

SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinomaSemantic proximity Read

Entanglement of Methylation Changes and cGAS-STING Signaling in Non-Small-Cell Lung CancerSemantic proximity Read