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Article

Dual-specific phosphatase 5 (DUSP5), upregulated in lung adenocarcinoma, as a potential therapeutic target for lung cancer.

Biochemical and biophysical research communications - 1 Oct 2025

Kawabe Nozomi, Komeda Kazuki, Muraki Nao, Sunaga Noriaki, Taguchi Ayumu, Iwabe Ayana, Minna John D, Tanaka Ichidai, Matsushima Miyoko, Kawabe Tsutomu, Sato Mitsuo

Abstract excerpt

Dual specific phosphatases (DUSPs) are a family of phosphatases, including DUSP4, DUSP5, and DUSP6, that function as negative regulators of the RAF/MEK/ERK pathway. These DUSPs have been extensively studied in various human cancers, particularly those with KRAS mutations. Our previous research indicated that these DUSPs are downregulated by KRAS knockdown in KRAS mutant lung cancer cell lines and upregulated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40939510
DOI: 10.1016/j.bbrc.2025.152595

Genes

DUSP5
KRAS
BRAF
EGFR
DUSP4
DUSP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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