Article

A Network Polypharmacological Approach to Combinatorial Drug Repurposing for Diffuse Intrinsic Pontine Glioma

2020-06-15

Abstract excerpt

Despite five decades of clinical investigations, there is currently no effective treatment for children diagnosed with Diffuse Intrinsic Pontine Glioma (DIPG). We now understand that DIPGs share the same histone 3 mutation and fatal prognosis as other diffuse midline gliomas (DMGs), which led to the introduction of a new entity referred to as DMG, H3 K27M mutant. Indeed, therapeutics indicated for other brain neop...

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Literature Corpus work: bd11cd9b-aa8e-5f77-87c7-d0c0d3c389ed
DOI: 10.1101/2020.06.14.150714

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