Article

Effective holistic characterization of small molecule effects using heterogeneous biological networks

2022-03-27

Abstract excerpt

<h4>ABSTRACT</h4> The two most common reasons for attrition in therapeutic clinical trials are efficacy and safety. We integrated heterogeneous data to create a human interactome network that was used to comprehensively describe drug behavior in biological systems, with the goal of accurate therapeutic candidate generation. The Computational Analysis of Novel Drug Opportunities (CANDO) platform for shotgun multis...

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Literature Corpus work: 4c6bd1ee-f791-5bc9-a352-38d011d613e4
DOI: 10.1101/2022.03.23.485550

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