Article
A disease model for Diffuse Intrinsic Pontine Glioma (DIPG) with mutations in TP53 and its application for drug repurposing
2022-06-27
Abstract excerpt
1.1 Brain cancers are ones of most aggressive and difficult to treat cancers. Despite numerous studies of the cellular mechanisms of gliomas, it is difficult to stop tumor growth. A complex genetic and epigenetic nature of many gliomas and poorly known pathways of human neuron precursors maturation suggest turning to big data analysis to find new insights and directions for drug development. We developed in silico...
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Identifiers and source
- Literature Corpus work
- 606e28e1-90ca-50db-95cb-aec6265ad227
- DOI
- 10.1101/2022.06.22.22276788