Article

Multi-layer guilt-by-association-based drug repurposing by integrating clinical knowledge on biological heterogeneous networks

2022-11-24

Abstract excerpt

<h4>ABSTRACT</h4> Computational drug repurposing attempts to leverage rapidly accumulating high-throughput data to discover new indications for existing drugs, often by clarifying biological mechanisms with relevant genes. Leveraging the Guilt-by-association (GBA), the principle of “similar genes share similar functions,” we introduced clinical neighbors of drug and disease entities while learning their mechanis...

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Literature Corpus work: ba54e57c-bb7b-5425-a02b-792e74981a47
DOI: 10.1101/2022.11.22.517225

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