Article

Copy number footprints of platinum-based anticancer therapies

2022-11-24

Abstract excerpt

Recently, distinct mutational footprints observed in metastatic tumors, secondary malignancies and normal human tissues have been demonstrated to be caused by the exposure to several chemotherapeutic drugs. These characteristic mutations originate from specific lesions caused by these chemicals to the DNA of exposed cells. However, it is unknown whether the exposure to these chemotherapies leads to a specific foot...

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Literature Corpus work: bd1009fd-8326-5527-9555-ed875f8152b9
DOI: 10.1101/2022.11.24.517816

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