Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Copy number footprints of platinum-based anticancer therapies.

PLoS genetics - 1 Feb 2023

Gonzalez Santiago, Lopez-Bigas Nuria, Gonzalez-Perez Abel

Abstract excerpt

Recently, distinct mutational footprints observed in metastatic tumors, secondary malignancies and normal human tissues have been demonstrated to be caused by the exposure to several chemotherapeutic drugs. These characteristic mutations originate from specific lesions caused by these chemicals to the DNA of exposed cells. However, it is unknown whether the exposure to these chemotherapies leads to a specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplasms
Share to Platinum
Share to Antineoplastic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Aberrations

Share to DNA Copy Number Variations

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 36780550
DOI: 10.1371/journal.pgen.1010634
PMCID: PMC9956877

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Copy number footprints of platinum-based anticancer therapies.PMID 36780550Read ↗

Copy number footprints of platinum-based anticancer therapiesSemantic proximity Read ↗

The mutational footprints of cancer therapiesSemantic proximity Read ↗

The mutational footprints of cancer therapies.Semantic proximity Read ↗

Novel next-generation sequencing-based methodologies to characterize the mutational consequences of (prenatal) chemotherapy exposure in noncancerous tissue.Semantic proximity Read ↗

Mutagenic impact and evolutionary influence of radiotherapy in hematologic malignanciesSemantic proximity Read ↗

In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumorsSemantic proximity Read ↗

The repertoire of copy number alteration signatures in human cancer.Semantic proximity Read ↗

Considering the cancer consequences of altered DNA polymerase functionSemantic proximity Read ↗

In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors.Semantic proximity Read ↗

Genomic landscape of platinum resistant and sensitive testicular cancers.Semantic proximity Read ↗

Mutational footprint of platinum chemotherapy in a secondary thyroid cancerSemantic proximity Read ↗

Polymerase ι promotes C>T substitutions in smoking models and in the platinum chemotherapy-induced SBS31 mutation signature.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.