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The Tradeoffs Between Persistence and Mutation Rates at Sub-Inhibitory Antibiotic Concentrations in <i>Staphylococcus aureus</i>

2024-04-01

Abstract excerpt

The rational design of the antibiotic treatment of bacterial infections employs these drugs to reach concentrations that exceed the minimum needed to prevent the replication of the target bacteria. However, within a treated patient, spatial and physiological heterogeneity promotes antibiotic gradients such that the concentration of antibiotics at specific sites is below the minimum needed to inhibit bacterial grow...

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Literature Corpus work
bd095c56-7f66-5fd1-8a29-e0c0aadbed64
DOI
10.1101/2024.04.01.587561
Open publication

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The Tradeoffs Between Persistence and Mutation Rates at Sub-Inhibitory Antibiotic Concentrations in <i>Staphylococcus aureus</i>DOI 10.1101/2024.04.01.587561
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