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Article

The tradeoffs between persistence and mutation rates at sub-inhibitory antibiotic concentrations in Staphylococcus aureus.

Microbiology spectrum - 1 Apr 2025

Ismail Alysha S, Berryhill Brandon A, Gil-Gil Teresa, Manuel Joshua A, Smith Andrew P, Baquero Fernando, Levin Bruce R

Abstract excerpt

The rational design of the antibiotic treatment of bacterial infections employs these drugs to reach concentrations that exceed the minimum needed to prevent the replication of the target bacteria. However, within a treated patient, spatial and physiological heterogeneity promotes antibiotic gradients such that the concentration of antibiotics at specific sites is below the minimum needed to inhibit bacterial...

Read the complete abstract on PubMed

Topics

Anti-Bacterial Agents
Staphylococcus aureus
Microbial Sensitivity Tests
Staphylococcal Infections
Mutation Rate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drug Resistance, Bacterial

Humans

Mutation

Computer Simulation

Source

Open in PubMed Open full text

Identifiers

PMID: 40035534
DOI: 10.1128/spectrum.02479-24
PMCID: PMC11960066

Provenance

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