Back to search

Article

Antibiotics at Clinical Concentrations Show Limited Effectivity Against Acute and Chronic Intracellular <i>S. aureus</i> Infections in Osteocytes

2023-12-18

Abstract excerpt

<h4>Objectives</h4> Case numbers of osteomyelitis are rising and chronic infections remain difficult to cure. While it is known that the major pathogen Staphylococcus aureus can persist intracellularly in osteocytes, the effectivity of antibiotics against this condition remains largely unknown. We sought to determine if current clinically utilised antibiotics were capable of clearing an intracellular osteocyte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b60a3e1e-e82c-5955-8a94-be296d139ddf
DOI
10.1101/2023.12.17.572089
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Antibiotics at Clinical Concentrations Show Limited Effectivity Against Acute and Chronic Intracellular <i>S. aureus</i> Infections in OsteocytesDOI 10.1101/2023.12.17.572089
The Complex Intracellular Lifecycle of Staphylococcus aureus Contributes to Reduced Antibiotic Efficacy and Persistent BacteremiaSemantic proximity
The Complex Intracellular Lifecycle of Staphylococcus aureus Contributes to Reduced Antibiotic Efficacy and Persistent BacteremiaSemantic proximity
Staphylococcus aureus persistence in osteocytes: weathering the storm of antibiotics and autophagy/xenophagySemantic proximity
Evasion of host defenses by intracellular Staphylococcus aureus.Semantic proximity
The osteoclast intracellular environment fosters bacterial growth during <i>Staphylococcus aureus</i> infectionSemantic proximity
Understanding Staphylococcus aureus internalisation and induction of antimicrobial toleranceSemantic proximity
<i>Staphylococcus aureus</i> adopts revertible intracellular viable-but-non-culturable phenotypes in chronic osteocyte infectionsSemantic proximity
Mechanisms of Antibiotic Failure During Staphylococcus aureus OsteomyelitisSemantic proximity
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.Semantic proximity
Post-fluoroquinolone treatment molecular events and nutrient availability modulate <i>Staphylococcus aureus</i> antibiotic persistenceSemantic proximity
Adaptive processes of<i>Staphylococcus aureus</i>isolates during the progression from acute to chronic bone and joint infections in patientsSemantic proximity
When antibiotics fail: a clinical and microbiological perspective on antibiotic tolerance and persistence of Staphylococcus aureusSemantic proximity
Select a neighboring publication to make it the new centre.