Article

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumourigenesis

2024-09-13

Abstract excerpt

Cell fate plasticity enables development, yet unlocked plasticity is a cancer hallmark. Regulating cell identity requires gene activation and repression. While master regulators induce lineage-specific genes to restrict plasticity, it remains unclear whether unwanted plasticity is actively suppressed by lineage-specific repressors. Here, we computationally predict so-called safeguard repressors for 18 cell types t...

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Literature Corpus work: bcfe30b1-e235-5176-9682-dfc5601d5d20
DOI: 10.1101/2024.09.10.612045

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