Article

Mitochondrial Dysfunction and Fatigue in Sjögren’s Disease

2024-06-19

Abstract excerpt

<h4>Objectives</h4> Sjögren’s disease (SjD) is a common exocrine disorder typified by chronic inflammation and dryness, but also profound fatigue, suggesting a pathological basis in cellular bioenergetics. In healthy states, damaged or dysfunctional mitochondrial components are broken down and recycled by mitophagy, a specialized form of autophagy. In many autoimmune disorders, however, evidence suggests that dys...

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Literature Corpus work: bcfbe7a3-a90a-51aa-853d-8dee9e513e0b
DOI: 10.1101/2024.06.17.598269

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