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Mitochondrial dysfunction and fatigue in Sjögren’s disease

1 Apr 2025

Abstract excerpt

OBJECTIVE: Sjögren's disease (SjD) is a chronic exocrine disorder typified by inflammation and dryness, but also profound fatigue, suggesting a pathological basis in cellular bioenergetics. In healthy states, dysfunctional mitochondria are recycled by mitophagic processes; when impaired, poorly functioning mitochondria persist and produce inflammatory reactive oxygen species. Employing a case-control study, we...

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PMID: 40274303
DOI: 10.1136/rmdopen-2024-005046

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