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Article

Pan-cancer analysis identifies PD-L2 as a tumor promotor in the tumor microenvironment

16 Mar 2023

Abstract excerpt

Background Programmed cell death protein 1 (PD-1) receptor has two ligands,programmed death-ligand 1 (PD-L1) and PD-L2. When compared with PD-L1, PD-L2 has not received much attention, and its role remains unclear. Methods The expression profiles of pdcd1lg2 (PD-L2-encoding gene) mRNA and PD-L2 protein were analyzed using TCGA, ICGC, and HPA databases. Kaplan-Meier and Cox regression analyses were used to assess...

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PMID: 37006239
DOI: 10.3389/fimmu.2023.1093716

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