Article

Signatures of defective DNA repair and replication in early-onset renal cancer patients referred for germline genetic testing

2022-05-25

Abstract excerpt

Early-onset renal cell carcinoma (eoRCC) is typically associated with pathogenic germline variants (PGVs) in RCC familial syndrome genes. However, most eoRCC patients lack PGVs in familial RCC genes and their genetic risk remains undefined. Here, we analyzed biospecimens from 22 eoRCC patients that were seen at our institution for genetic counseling and tested negative for PGVs in RCC familial syndrome genes. We p...

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Literature Corpus work: bcb0fb7e-30ca-508d-9550-9550953b1a12
DOI: 10.1101/2022.05.23.22275227

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