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Somatic mutations in the DNA repairome in prostate cancers in African Americans and Caucasians

16 Apr 2020

Abstract excerpt

Most hereditary tumors show aberrations in DNA repair genes or their regulators. In contrast, only a minority of sporadic tumors show alterations in these genes. As a result, genomic instability is currently considered an enhancer of tumorigenesis rather than an obligatory event in this process. However, tumor heterogeneity presents a significant technical challenge for most cancer genomics studies performed at...

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PMID: 32300177
DOI: 10.1038/s41388-020-1280-x

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