Article

Prevalence of pathogenic variants in DNA damage response genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer

2020-02-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Pathogenic variants (PVs) in a number of genes are known to increase the risk of hereditary renal cancer (hRC). However, many early-onset RC (eoRC) patients undergoing genetic testing lack PVs in hRC genes; thus, their genetic risk remains undefined. To determine if PVs in DNA damage response (DDR) genes are enriched in a convenience sample of eoRC patients undergoing genetic t...

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Literature Corpus work: 37730156-1cf2-57e8-8030-3e9dbff0a92a
DOI: 10.1101/2020.02.21.958256

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