Article

N-glycolyl chondroitin synthesis using metabolically engineered E. coli

2020-08-05

Abstract excerpt

<title>Abstract</title> <p><italic>N</italic>-glycolyl chondroitin (Gc-CN) is a metabolite of <italic>N</italic><bold>-</bold>glycolylneuraminic acid (Neu5Gc), a sialic acid<italic> </italic>that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat. Neu5Gc cannot be biosynthesized by humans due to an evolutionary mutation and has been implic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc79dd30-0415-551b-ab8e-0d3fa6879526
DOI: 10.21203/rs.3.rs-35611/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

N-glycolyl chondroitin synthesis using metabolically engineered E. coliDOI 10.21203/rs.3.rs-35611/v2Read

Engineering β-1,4-galactosyltransferase to Enhance Lacto-N-neotetraose Production in Corynebacterium glutamicumSemantic proximity Read

Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteriaSemantic proximity Read

[Proteoglycan core glycosyltransferases].Semantic proximity Read

Metabolic Engineering Of <i>Lactococcus Lactis</i> For The Production Of HeparosanSemantic proximity Read

Identification and biochemical characterization of a novel chondroitin sulfate/dermantan sulfate lyase from Photobacterium sp.Semantic proximity Read

Combinatorial modular pathway engineering for guanosine 5′-diphosphate-L-fucose production in recombinant Escherichia coliSemantic proximity Read

Production of antibodies and antibody fragments containing non-natural amino acids in Escherichia coliSemantic proximity Read

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.Semantic proximity Read

Rational modification of Neisseria meningitidis β1,3-N-acetylglucosaminyltransferase for lacto-N-neotetraose synthesis with reduced long-chain derivativesSemantic proximity Read

Genetics behind the biosynthesis of nonulosonic acid containing lipooligosaccharides in <i>Campylobacter coli</i>Semantic proximity Read

Beneficial base substitutions in Escherichia coli fucO gene for enhancement of glycolic acid production.Semantic proximity Read

Prebiotic Properties of Bacillus Coagulans MA 13: Production of Galactoside Hydrolyzing Enzymes and Characterization of the Transglycosylation Properties of a GH42 β-GalactosidaseSemantic proximity Read