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Beneficial base substitutions in Escherichia coli fucO gene for enhancement of glycolic acid production.

Journal of bioscience and bioengineering - 1 Oct 2024

Nemoto Mayu, Muranushi Wataru, Shuting Chen, Saito Yusuke, Sugimori Daisuke, Yamada Miwa

Abstract excerpt

Microbial production of glycolic acid (GA) from ethylene glycol is extensively used in a variety of industries because ethylene glycol is not only an inexpensive raw material but also the main component of industrial wastes. In this study, we produced GA from ethylene glycol using Escherichia coli overexpressing the endogenous 1,2-propanediol oxidoreductase (fucO) and lactaldehyde dehydrogenase (aldA) genes. To...

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PMID: 39079834
DOI: 10.1016/j.jbiosc.2024.06.007

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