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Article

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

PloS one - 1 Jan 2009

Diaz Sandra L, Padler-Karavani Vered, Ghaderi Darius, Hurtado-Ziola Nancy, Yu Hai, Chen Xi, Brinkman-Van der Linden Els C M, Varki Ajit, Varki Nissi M

Abstract excerpt

BACKGROUND: Humans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids of human tumors, fetuses and some normal tissues. Metabolic incorporation of Neu5Gc from animal-derived cells and medium components also results in variable...

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PMID: 19156207
DOI: 10.1371/journal.pone.0004241
PMCID: PMC2626223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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