Article

The Structure of Human Tyrosine Hydroxylase Reveals the Mechanism for Feedback Inhibition by Dopamine

2020-09-16

Abstract excerpt

<title>Abstract</title> <p>Tyrosine hydroxylase (TH) is a highly regulated enzyme that catalyses the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines. Mutations and dysfunction in this enzyme lead to DA deficiency and parkinsonisms of different severity. An understanding of TH deficiency at the level of structure and stability has been lacking to date, as only structures of truncat...

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Literature Corpus work: 70addc8e-c58f-527d-b92f-5894dd70454a
DOI: 10.21203/rs.3.rs-64971/v1

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