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Article

Genome-Wide Association Analysis Identifies LILRB2 Gene for Pathological Myopia.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Oct 2024

Jiang Lingxi, Huang Lulin, Dai Chao, Zheng Rui, Miyake Masahiro, Mori Yuki, Nakao Shin-Ya, Morino Kazuya, Ymashiro Kenji, Miao Yang-Bao, Li Qi, Ren Weiming, Ye Zimeng, Li Hongjing, Yang Zhenglin, Shi Yi

Abstract excerpt

Pathological myopia (PM) is one of the leading causes of blindness, especially in Asia. To identify the genetic risk factors of PM, a two-stage genome-wide association study (GWAS) and replication analysis in East Asian populations is conducted. The analysis identified LILRB2 in 19q13.42 as a new candidate locus for PM. The increased protein expression of LILRB2/Pirb (mouse orthologous protein) in PM patients and...

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Identifiers

PMID: 39207058
DOI: 10.1002/advs.202308968
PMCID: PMC11516067

Genes

LILRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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