Article

SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell

2022-06-17

Abstract excerpt

Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in both type 1 and type 2 diabetes; however, the mechanisms underlying impaired proinsulin processing remain incompletely understood. Here, we identify the sarcoendoplasmic reticulum Ca 2+ ATPase-2 (SERCA2) pump and β cell ER Ca 2+ as key regulators of systemic glucose tolerance and proinsulin processing. We...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc58242f-cffb-5b69-a09e-d8dc809e6ebd
DOI: 10.1101/2022.06.13.495980

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cellDOI 10.1101/2022.06.13.495980Read

Control of precursor maturation and disposal is an early regulative mechanism in the normal insulin production of pancreatic β-cells.Semantic proximity Read

Adipocyte-specific ablation of the Ca <sup>2+</sup> pump SERCA2 impairs whole-body metabolic function and reveals the diverse metabolic flexibility of white and brown adipose tissueSemantic proximity Read

β-cell NCK1 is reduced in type 2 diabetes, leading to inefficient β-cell UPR and insulin secretion and revealing sex-specific adaptation during metabolic stressSemantic proximity Read

Wolfram syndrome 2 gene (CISD2) deficiency disrupts Ca2+-mediated insulin secretion in β-cellsSemantic proximity Read

Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes.Semantic proximity Read

Sorting receptor SORCS2 facilitates a protective stress response in pancreatic isletsSemantic proximity Read

Pancreatic islets undergo functional and morphological adaptation during development of Barth SyndromeSemantic proximity Read

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.Semantic proximity Read

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.Semantic proximity Read

Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperonesSemantic proximity Read

Maturation of beta cells: lessons from in vivo and in vitro modelsSemantic proximity Read

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell DysfunctionSemantic proximity Read