Article

Coenzyme A is bound to tafazzin – a paradigm change for transacylation

2026-02-07

Abstract excerpt

Cardiolipin (CL) is the signature phospholipid of mitochondria. In an obligatory remodeling process, the mitochondrial transacylase tafazzin exchanges its acyl chains to create the highly unsaturated, mature form of CL. Tafazzin dysfunction causes Barth syndrome, a severe multisystem disorder. We determined the structure of tafazzin at a resolution of 2.2 Å using cryo-electron microscopy (cryo-EM). Until now, the...

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Literature Corpus work: bc4c2226-d254-5c6b-a063-881a4c190ca3
DOI: 10.64898/2026.02.05.703992

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