Article
Deacylation on the matrix side of the mitochondrial inner membrane regulates cardiolipin remodeling.
Molecular biology of the cell - 1 Jun 2013
Baile Matthew G, Whited Kevin, Claypool Steven M
Abstract excerpt
The mitochondrial-specific lipid cardiolipin (CL) is required for numerous processes therein. After its synthesis on the matrix-facing leaflet of the inner membrane (IM), CL undergoes acyl chain remodeling to achieve its final form. In yeast, this process is completed by the transacylase tafazzin, which associates with intermembrane space (IMS)-facing membrane leaflets. Mutations in TAZ1 result in the X-linked...
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