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Article

The Function of Tafazzin, a Mitochondrial Phospholipid-Lysophospholipid Acyltransferase.

Journal of molecular biology - 21 Aug 2020

Schlame Michael, Xu Yang

Abstract excerpt

Tafazzin is a mitochondrial enzyme that exchanges fatty acids between phospholipids by phospholipid-lysophospholipid transacylation. The reaction alters the molecular species composition and, as a result, the physical properties of lipids. In vivo, the most important substrate of tafazzin is the mitochondria-specific lipid cardiolipin. Tafazzin mutations cause the human disease Barth syndrome, which presents with...

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Identifiers

PMID: 32234310
DOI: 10.1016/j.jmb.2020.03.026
PMCID: PMC7483898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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