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Article

The lipid environment modulates cardiolipin and phospholipid constitution in wild type and tafazzin-deficient cells.

Journal of inherited metabolic disease - 1 Jan 2022

Oemer Gregor, Koch Jakob, Wohlfarter Yvonne, Lackner Katharina, Gebert Rita E M, Geley Stephan, Zschocke Johannes, Keller Markus A

Abstract excerpt

Deficiency of the transacylase tafazzin due to loss of function variants in the X-chromosomal TAFAZZIN gene causes Barth syndrome (BTHS) with severe neonatal or infantile cardiomyopathy, neutropenia, myopathy, and short stature. The condition is characterized by drastic changes in the composition of cardiolipins, a mitochondria-specific class of phospholipids. Studies examining the impact of tafazzin deficiency...

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Identifiers

PMID: 34494285
DOI: 10.1002/jimd.12433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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