Article

A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis

2021-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are detectable in numerous tumor entities and linked with poor prognosis in some of these, such as Sonic Hedgehog medulloblastoma, neuroblastoma and osteosarcoma. Hence, there is a...

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Literature Corpus work: b8c6b17b-660d-5058-804e-91f1764d16f3
DOI: 10.1101/2021.04.22.440879

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